| Unlockable: | How to Unlock: |
| Agents of S.H.I.E.L.D : +5 to all Resistances | Captain America, Nick Fury, Spider-Woman, Wolverine |
| Agile Warriors : 10% Reduced Energy Cost | Black Panther, Daredevil, Deadpool, Elektra, Spider-Man |
| Air Force: +15% Max Health | Human Torch, Ms. Marvel, Storm and Thor |
| Alternate Identities: +5% Criticals | Ghost Rider (Western), Iron Man (War Machine), Ms. Marvel (Ventura), Spider-Woman (Secret Wars), Thor (Beta Ray Bill) |
| Assassins: +60% Credit Drop | Blade, Deadpool, Elektra, Wolverine |
| Avengers : +5% damage | Captain America, Thor, Iron Man, Spider-Woman, Ms. Marvel |
| Bad to the Bone: 5% Damage Inflicted Goes to Health | Blade, Ghost Rider, Luke Cage, Wolverine |
| Bruisers : +15 Striking | Thing, Captain America, Luke Cage, Ms. Marvel |
| Classic Avengers: +5% Damage | Black Panther, Captain America, Iron Man and Thor |
| Dark Past: +5% XP | Blade, Elektra, Ghost Rider, Spider-Woman |
| Defenders : 5% Damage inflicted goes to Health | Dr.Strange, Iceman, Luke Cage, Silver Surfer |
| Double Date: +5 Health Regen | Black Panther, Invisible Woman, Mr. Fantastic, Storm |
| Fantastic Four: +20 Health Per Knockout | Thing, Invisible Woman, Human Torch and Mr. Fantastic |
| Femme Fatale : +5% Damage | Ms. Marvel, Storm, Invisible Woman, Elektra, Spider-Woman |
| Flashback: +15% Max Health | Captain America (WWII), Daredevil (Original), Ghost Rider (Original), Iceman (Original), IronMan (Classic), Ms. Marvel (Original), Wolverine (Classic) |
| Martial Artists: +15 Striking | Black Panther, Captain America, Daredevil, Nick Fury |
| Marvel Knights: +6 Body, Strike, and Focus | Dr. Strange, Daredevil, Luke Cage, Spiderman, Black Panther |
| Marvel Royalty: +60% Credits Dropped | Black Panther, Dr. Strange, Storm, Thor |
| Natural Forces : 5%Dmg inflicted as Health Gain | Thor, Strom, Human Torch, Ice Man |
| Natural Leaders: +5% XP | Captain America, Dr. Strange, Mr. Fantastic, Nick Fury, Storm |
| New Avengers : +5% All Resistances | Captain America, Luke Cage, Wolverine, Spider-Man, Spider-Woman, Iron Man |
| New Fantastic Four : 15% Max Energy | Ghostrider, Luke Cage, Spider-man, Wolverine |
| Power Platoon : 20 Energy per KO | Silver Surfer, Iron Man, Ms. Marvel, Thor |
| Raven Ultimates: +6 Striking, Body, and Focus | Silver Surfer, Deadpool, Thing, Invisible Woman, Iceman |
| Scorchers: +10% Reduced Power Cost | Ghost Rider Human Torch, Storm, Thor |
| Supernatural: +5 Health Regen | Blade, Dr. Strange, Ghost Rider, Thor |
| Think Tanks: +15% to Max Health | Iron Man, Spider-Man, Mr. Fantastic, Dr. Strange |
| Weapon Specialists: +5% Criticals | Blade, Captain America, Deadpool, Elektra, Nick Fury |
| Code: | Result: |
| Press Up(3), Left, Right, Left at the team menu. | 100K |
| Press Up(2), Down(2), Left(3), Start at a S.H.E.I.L.D. save zone menu or the main menu. | All characters |
| Press Up, Left(2), Up, Right(2), Up at the Review menu. | All Cinematics |
| Press Left, Right(2), Left, Up(2), Right at the Review menu. | All Comics |
| Press Down(3), Right(2), Left, Down at the Review menu. | All Concept Art |
| Press Up, Down, Up, Down, Left, Right, Left, Right, Up, Down, Start at a S.H.E.I.L.D. save zone menu or the main menu. | All costumes |
| Press Left, Right, Left, Right, Up, Down, Up, Down, Left, Right, Start at a S.H.E.I.L.D. save zone menu or the main menu. | All powers |
| Press Up, Down, Right, Left, Up(2), Down at the Review menu. | All Wallpapers |
| Press Left, Right(2), Left, Up, Down(2), Up during game play. | Filler |
| Press Up, Down, Up, Down, Up, Left, Down, Right during game play. | God Mode |
| Press Up, Left, Up, Left, Down, Right, Down, Right at the team menu. | Level 99 |
| Press Up, Left, Up, Right, Down, Right during game play. | Super Speed |
| Press Up, Right, Left, Down, Up, Right, Left, Down at the Comic Book mission menu. | The Courses |
| Press Left, Right, Down(2), Right, Left during game play. | Touch of Death |