| Unlockable: | How to Unlock: |
| Agent Muriel Green Files (25 points) | Complete The Path of Souls on Hard. |
| Antadurunnu Dossier (20 points) | Complete The God Seal on Hard. |
| Arnold Leach Dossier (20 points) | Finish Al Khali - Complete Al Khali on either Easy or Normal. |
| Bishop Maltheus Dossier (15 points) | Finish Crusades - Complete Crusades on either Easy or Normal. |
| Blind Behemoth Dossier (30 points) | Complete Morituri te salutant on Hard without being incapacitated. |
| Brother William of Auxerre Files (20 points) | Complete Motley Crew on Hard. |
| Centurion Tertius Longinus Files (30 points) | Complete Decadence on Hard without being incapacitated. |
| Child Crusader Dossier (30 points) | Complete Imperium on Hard without being incapacitated. |
| Corpses Behemoth Dossier (20 points) | Complete Rivers of Blood on Hard. |
| Cpl. Simone Cole Files (20 points) | Complete The Tomb on Hard. |
| Cpt. Devin Ross Files (15 points) | Grasshopper of Battery - Kill 50 enemies using Melee Attacks. |
| Cpt. Xavier Jones Files (20 points) | Complete Man Down on Hard. |
| Crossbowman Crusader Dossier (20 points) | Complete Tortured Souls on Hard. |
| Cultist Dossier (30 points) | Master of Battery - Kill 100 enemies using Melee Attacks. |
| Deceased Devin Ross Files (5 points) | Complete Still With You on Hard. |
| Enlil Sumerian Demon Dossier (20 points) | Complete Spiritual Guide on Hard. |
| Explosive Cultist Dossier (10 points) | Grasshopper of BOOM - Disintegrate 50 enemies! |
| Flamethrower Dossier (25 points) | Master of BOOM - Disintegrate 100 enemies! |
| Flying Cultist Dossier (50 points) | God of Pop - Pop 250 heads! |
| Fr. Paul Rawlings Files (20 points) | Master of Pop - Pop 100 heads! |
| Gladiator Dossier (20 points) | Complete Temple of Pain on Hard. |
| Governor Cassus Vicus Dossier (20 points) | Finish Rome - Complete Rome on either Easy or Normal. |
| Grenadier Dossier (25 points) | Master of Ghost - Kill 100 enemies using Ghost Bullet. |
| Inanna Sumerian Demon Dossier (20 points) | Complete Skin on Hard. |
| Ki Sumerian Demon Dossier (20 points) | Complete Flesh on Hard. |
| Legionary Dossier (20 points) | Complete The Low Road on Hard. |
| Lt. Abigail Black Files (10 points) | Grasshopper of Ghost - Kill 50 enemies using Ghost Bullet. |
| Machinegunner Dossier (50 points) | God of Ghost - Kill 250 enemies using Ghost Bullet. |
| Nanna Sumerian Demon Dossier (20 points) | Complete Blood on Hard. |
| Ninlil Sumerian Demon Dossier (30 points) | Complete Skin on Hard without being incapacitated. |
| Operation: Godseal Files (20 points) | Complete Exorcism on Hard. |
| OSS British Commandos Files (50 points) | God of BOOM - Disintegrate 250 enemies! |
| Psychic Commander Dossier (10 points) | Finish World War 2 - Complete World War 2 on either Easy or Normal. |
| Pyxis Prima Dossier (25 points) | Finish Sumeria - Complete Sumeria on either Easy or Normal. |
| Sgt. Frank Delgado Files (10 points) | Grasshopper of Pop - Pop 50 heads! |
| Sgt. Wilhelmina Church Files (20 points) | Complete Al Khali on Hard. |
| Sir Richard de Grey Dossier (20 points) | Complete Out of the Frying Pan on Hard. |
| Sumerian Puppet Dossier (30 points) | Complete Flesh on Hard without being incapacitated. |
| The Firstborn Portfolio (55 points) | God of Battery - Kill 250 enemies using Melee Attacks. |
| The Jericho Team Portfolio (30 points) | Complete Rivers of Blood on Hard without being incapacitated. |
| Utu Sumerian Demon Dossier (30 points) | Complete Blood on Hard without being incapacitated. |
| Warrior Crusader Dossier (20 points) | Complete Sewers on Hard. |