| Unlockable: | How to Unlock: |
| 100 Million!?! Gulp!?! (30 points) | Earn 100,000,000 points total in Career. |
| A Couple of Streakers (5 points) | Earn a 200 note streak in a Co-op match. |
| Always Hard (15 points) | Complete Career on the Hard difficulty. |
| Axe Collector (5 points) | Buy all the Guitars from the shop. |
| Axe Grinder (10 points) | Earn 5 stars on all songs on the Easy difficulty. |
| Back Up Hero (10 points) | Complete all songs as the back-up guitar player. |
| Big 'Ol Pile of Wins (20 points) | Win 500 Online Ranked matches. |
| Bronze Streaker (5 points) | Earn a 100 note Streak in Career or Quick Play. |
| Burnin' a Hole in Your Pocket (10 points) | Buy everything from the store. |
| Button Masher (5 points) | Win 15 consecutive Ranked songs online using a standard controller. |
| Buy a Guitar Already (15 points) | Play through a career on the Hard or Expert difficulty using a standard controller. |
| Dynamic Duo (15 points) | Earn a 1000 note streak in a Co-op match. |
| Easy Duo (10 points) | Earn 5 stars on all Co-op songs for the Easy difficulty. |
| Easy Rider (5 points) | Complete a Career on the Easy Difficulty. |
| Enlightened Guitarist (30 points) | Gold Star 20 songs on Expert. |
| First Big Score (5 points) | Score 250,000 on a song. |
| Gold Streaker (15 points) | Earn a 500 note streak in Career or Quick Play. |
| Got 'em All (5 points) | Buy all characters from the shop. |
| Guitar Hero (75 points) | Earn 5 stars on all songs on the Expert difficulty. |
| Guitar Wizard (10 points) | Complete all Co-op as the lead guitarist. |
| Half a Mill' (10 points) | Score 500,000 on a song. |
| Half Mill' Club (10 points) | Score 500,000 on any song in a Co-op match. |
| Hard Duo (30 points) | Earn 5 stars on all Co-op songs on the Hard difficulty. |
| Hendrix Reborn (10 points) | Complete Career Lefty and Righty. |
| Higher Than Most (20 points) | Score 700,000 on any song in a Co-op match. |
| Leaders of the Pack (10 points) | 100% a song in a Co-op match. |
| Life of the Party (10 points) | Host Ranked Online matches and win 15 consecutive songs. |
| Living Legends (75 points) | 5 Star all Co-op songs on Expert. |
| Medium Duo (20 points) | Earn 5 stars on all Co-op songs for the Medium difficulty. |
| Medium Rare (10 points) | Complete Career Mode on the Medium difficulty. |
| Meet Your Maker (20 points) | Beat one of the creators of Guitar Hero 3 at their own game. |
| Millionaire Club (20 points) | Score 1,000,000 on any song in a Co-op match. |
| Never Gonna Spend It All (10 points) | Earn $350,000 in career lifetime earnings. |
| Now That's Impressive (20 points) | Score 750,000 on a song. |
| Perfectionist (10 points) | 100% a song. |
| Ready to Rock (5 points) | Complete the tutorial. |
| Right Hand of God (20 points) | Complete Career Mode on the Expert difficulty. |
| Rock Guru (20 points) | Earn 5 stars on all songs on the Medium difficulty. |
| Search and Destroy (10 points) | Join Ranked Online matches and win 15 consecutive songs. |
| Shredder (30 points) | Earn 5 stars on all songs on the Hard difficulty. |
| Silver Streaker (10 points) | Earn a 250 note streak in Career or Quick Play. |
| Solo Career (25 points) | Complete all Career difficulties. |
| Star Mania (15 points) | Activate Star Power 3 times on Through the Fire and Flames on Expert. |
| Streak Master (20 points) | Earn a 1000 note streak in Career or Quick Play. |
| Streak Masters (20 points) | Earn a 2000 note streak in a Co-op match. |
| Streaker (10 points) | Earn a 150 note streak in a Ranked Online Battle mode match. |
| That's What Friends Are For (25 points) | Complete Co-op Career. |
| The Inhuman Achievement (15 points) | Complete Through the Fire and Flames on Expert. |
| The Long Road Ahead (100 points) | Complete all difficulties in Career, buy everything from the shop and complete 100 online matches. |
| Tone Deaf (5 points) | Beat any song on the expert difficulty with the games sound options turned down to zero. |
| Too Many to Count (25 points) | Hit 250,000 notes in Career. |
| Track Master (5 points) | Buy all songs from the shop. |
| Two by Four (5 points) | Get an 8X multiplier in a Co-op game. |
| Two Timer (10 points) | Earn a 500 note streak in a Co-op match. |
| Whammy Mania (15 points) | Use the Whammy Bar on every held note on Number of the Beast. |
| Who Needs the Power (15 points) | 200k on Cult of Personality without Star Power. |